Tag Archives: cancer

Main Symptoms of Breast Ductal Carcinoma

Breast ductal carcinoma starts inside the milk ducts and is the most common type of breast cancer. Knowing how it usually shows up can help you spot it early and see a doctor sooner.

The first sign most women notice is a painless, firm lump in the breast. It may feel like a hard knot with uneven edges, and it doesn’t move around easily. The lump can be anywhere, but it’s often toward the under-arm side. Sometimes the skin over the lump dimples, looking like an orange-peel texture, or the nipple turns inward or points a different direction. You might feel thickening or a heavy, swollen area that wasn’t there before.

Nipple changes are another clue. The nipple can become scaly, red, or develop a crusty rash—signs that cancer cells are in the ducts right under the skin. Spontaneous clear or bloody discharge from one nipple, especially when only one duct is involved, should also be checked.

As the tumor grows, the breast can swell, feel warm, or change color. Lymph nodes under the arm may enlarge and feel like firm peas. Advanced cases can cause breast pain, skin ulcers, or swelling of the whole breast, but most early ductal cancers don’t hurt.

Any new lump, skin change, nipple pull, or unusual discharge that lasts more than a couple of weeks deserves a doctor’s exam and imaging.

SymptomWhat to Look For
LumpHard, uneven, painless knot that doesn’t shift easily
Skin changesDimpling, orange-peel texture, redness, warmth
Nipple changesNew inversion, scaling, crusty rash, or single-duct discharge (clear or bloody)
SwellingHeaviness, thickening, or size increase in one breast
Lymph nodesFirm, pea-sized lumps under the arm or above the collarbone

What Are the Symptoms of Intrahepatic Cholangiocarcinoma?

Intrahepatic cholangiocarcinoma (ICC) arises from bile ducts within the liver parenchyma. Early lesions are usually asymptomatic; as the tumor enlarges or metastasizes, the following complaints typically appear:

  1. Right-upper-quadrant pain
    A dull, continuous ache or vague fullness beneath the ribs is the most frequent early symptom; it may radiate to the back or shoulder.
  2. Palpable mass or hepatomegaly
    Patients or clinicians can feel a firm, nodular liver edge or localized lump that moves with respiration.
  3. Unintended weight loss & anorexia
    Rapid loss of >5 % body weight within weeks, early satiety and loss of interest in food are common systemic effects.
  4. Fatigue and night sweats
    Persistent tiredness, low-grade fever and drenching night sweats reflect cytokine release and tumor cachexia.
  5. Jaundice (less common than in hilar tumors)
    Yellow sclera/skin, dark urine and pale stools occur only when large tumors compress intra-hepatic bile radicals or invade the hepatic hilum.
  6. Pruritus
    Deposition of bile salts can produce intense, often intractable itching even before visible jaundice.
  7. Paraneoplastic signs
    Hypercalcaemia, hypoglycaemia or dermatomyositis occasionally precede other manifestations.

Because findings overlap with benign liver disease, any new combination of RUQ pain, weight loss and fatigue—especially in patients with cirrhosis, hepatitis or primary sclerosing cholangitis—should prompt urgent imaging and tumour-marker assessment.

Symptom / SignTypical Features
RUQ pain/heavinessDull ache, may radiate to shoulder
Palpable massFirm, nodular, moves with breathing
Weight loss>5 % in weeks, anorexia
Fatigue/night sweatsPersistent, low-grade fever
JaundiceLate, if bile radicals compressed
PruritusIntense, may precede icterus
ParaneoplasticHypercalcaemia, skin rash

What Are the Symptoms of Primary Liver Cancer?

Primary liver cancer (hepatocellular carcinoma, HCC) often begins silently; early-stage tumors rarely cause pain or obvious changes. As the lesion enlarges or invades adjacent structures, the following complaints typically appear:

  1. Right-upper-quadrant discomfort
    A dull, continuous ache or heaviness develops beneath the ribs and may radiate to the back or right shoulder.
  2. Palpable mass or abdominal swelling
    Patients or clinicians can feel a firm, nodular liver edge below the costal margin; progressive enlargement can produce visible asymmetry of the abdomen.
  3. Unintended weight loss & anorexia
    Rapid loss of >5 % body weight within weeks, early satiety and loss of interest in food are common systemic effects.
  4. Fatigue and weakness
    Persistent tiredness unrelated to exertion reflects both malignant cachexia and underlying chronic liver disease.
  5. Jaundice
    Yellow discoloration of sclerae and skin arises when tumour compression or portal vein invasion reduces bilirubin excretion.
  6. Ascites & peripheral oedema
    Fluid accumulates in the peritoneal cavity and ankles as portal hypertension and hypoalbuminaemia worsen.
  7. Pyrexia & night sweats
    Low-grade fever is present in ~30 % of cases, probably due to cytokine release or central tumour necrosis.
  8. GI bleeding
    Ruptured oesophageal or gastric varices may cause haematemesis or melaena when portal pressure rises.
  9. Paraneoplastic signs
    Hypercalcaemia, hypoglycaemia, erythrocytosis or cutaneous lesions (e.g., dermatomyositis) occasionally precede other manifestations.

Symptoms are often indistinguishable from decompensated cirrhosis; any new or worsening complaint in a cirrhotic patient warrants immediate imaging and tumour-marker assessment.

Symptom / SignTypical Features
RUQ pain/heavinessDull ache, may radiate to shoulder
Palpable massFirm, nodular, expands downwards
Weight loss>5 % in weeks, anorexia
FatiguePersistent, disproportionate
JaundiceYellow sclera, dark urine, pale stools
Ascites/oedemaBulging flanks, ankle swelling
FeverLow-grade, intermittent
GI bleedingHaematemesis, melaena
ParaneoplasticHypoglycaemia, skin rash

What Are the Symptoms of Gallbladder Cancer?

Gallbladder cancer is an aggressive malignancy that usually produces no specific early warning signs. Symptoms appear only when the tumour obstructs bile flow, invades adjacent organs, or becomes advanced.

  1. Right-upper-quadrant pain
    A constant, dull ache or colicky pain under the ribs is the most common first complaint; it may radiate to the right shoulder or back and is often mistaken for uncomplicated gallstone disease.
  2. Palpable mass
    A firm, non-tender swelling is sometimes felt in the upper abdomen when the tumour has enlarged or the gall-bladder is distended by associated stones.
  3. Jaundice
    Yellow discoloration of skin and sclera, dark urine and pale stools develop if the tumour compresses or invades the common bile duct.
  4. Unintended weight loss & anorexia
    Rapid loss of >5 % body weight, early satiety and general fatigue reflect malignant cachexia and reduced oral intake.
  5. Nausea and intolerance to fatty foods
    Patients report recurrent queasiness, bloating and diarrhoea after meals rich in fat.
  6. Fever & night sweats
    Low-grade, intermittent pyrexia is common; high fever with chills suggests acute cholecystitis or super-infection of an obstructed system.
  7. Alarm features
    Severe, unrelenting pain, progressive jaundice, ascites, or left-supraclavicular lymph-node enlargement indicate advanced disease with distant spread.

Because findings overlap with benign biliary disorders, any new combination of RUQ pain, weight loss and jaundice—especially in older patients with long-standing gallstones—should prompt urgent imaging and tumour-marker assessment.

SymptomTypical Presentation
RUQ painConstant or colicky, may radiate to shoulder
Palpable massFirm, non-tender upper-abdominal swelling
JaundiceYellow skin/sclera, dark urine, pale stools
Weight loss>5 % in weeks, anorexia
Fat intoleranceNausea, bloating, post-prandial diarrhoea
FeverLow-grade; high with infection
Alarm signsAscites, severe pain, distant nodes

What Are the Symptoms of Cholangiocarcinoma?

Cholangiocarcinoma (bile-duct cancer) is anatomically classified into intra-hepatic, peri-hilar and distal types. Early findings are usually non-specific; symptoms depend on where the tumour grows and how quickly it obstructs bile flow.

  1. Painless jaundice
    Yellow discoloration of skin and sclera plus dark urine and clay-coloured stools is the hallmark of peri-hilar or distal tumours that occlude the main bile ducts .
  2. Generalised pruritus
    Deposition of bile salts in the dermis produces intense, often intractable itching that may precede visible jaundice.
  3. Right-upper-quadrant pain
    A dull, non-colicky ache or sense of fullness develops as the mass enlarges or as the gall-bladder and liver capsule become stretched.
  4. Systemic features
    Fatigue, anorexia, low-grade fever and night sweats are common, while unexplained weight loss reflects tumour cachexia and reduced oral intake .
  5. Acute cholangitis picture
    Fluctuating fever with rigors, hypotension and confusion may occur if malignant obstruction becomes super-infected.
  6. Intra-hepatic variant
    Tumours within the liver parenchyma seldom obstruct major ducts early; they present with vague upper-abdominal discomfort, fatigue and weight loss, with jaundice appearing only late if at all .

Because early symptoms overlap with benign biliary disease, any new combination of jaundice, pruritus and weight loss—especially in patients over 50 or those with primary sclerosing cholangitis—should prompt urgent imaging and laboratory work-up.

SymptomTypical Presentation
Painless jaundiceYellow skin/sclera, dark urine, pale stools
PruritusIntense, may precede jaundice
RUQ pain/FullnessDull, non-colicky ache
Weight loss & fatigueRapid, unintended
Fever & night sweatsLow-grade, intermittent
Acute cholangitisRigors, hypotension, mental change

What Are the Symptoms of Liver Cancer?

Liver cancer—predominantly hepatocellular carcinoma (HCC)—often begins silently; early-stage tumours rarely cause pain or obvious changes. As the lesion enlarges or invades adjacent structures, the following complaints typically appear:

  1. Right-upper-quadrant discomfort
    A dull, continuous ache or heaviness develops beneath the ribs and may radiate to the back or right shoulder.
  2. Palpable mass or swelling
    Patients or clinicians can feel a firm, nodular liver edge below the costal margin; progressive enlargement can produce visible asymmetry of the abdomen.
  3. Unintended weight loss & anorexia
    Rapid loss of >5 % body weight within weeks, early satiety and loss of interest in food are common systemic effects.
  4. Fatigue and weakness
    Persistent tiredness unrelated to exertion reflects both malignant cachexia and underlying chronic liver disease.
  5. Jaundice
    Yellow discoloration of sclerae and skin arises when tumour compression or portal vein invasion reduces bilirubin excretion.
  6. Ascites & peripheral oedema
    Fluid accumulates in the peritoneal cavity and ankles as portal hypertension and hypoalbuminaemia worsen.
  7. Pyrexia & night sweats
    Low-grade fever is present in ~30 % of cases, probably due to cytokine release or central tumour necrosis.
  8. GI bleeding
    Ruptured oesophageal or gastric varices may cause haematemesis or melaena when portal pressure rises.
  9. Paraneoplastic signs
    Hypercalcaemia, hypoglycaemia, erythrocytosis or cutaneous lesions (e.g., dermatomyositis) occasionally precede other manifestations.

Symptoms are often indistinguishable from decompensated cirrhosis; any new or worsening complaint in a cirrhotic patient warrants immediate imaging and tumour-marker assessment.

Symptom / SignTypical Features
RUQ pain/heavinessDull ache, may radiate to shoulder
Palpable liver massFirm, nodular, expands downwards
Weight loss & anorexia>5 % loss, early satiety
FatiguePersistent, disproportionate
JaundiceYellow sclera/skin, dark urine
Ascites/oedemaBulging flanks, ankle swelling
FeverLow-grade, night sweats
GI bleedingHaematemesis, melaena
ParaneoplasticHypoglycaemia, skin rash