What Are the Symptoms of Thyroid Cancer?

Thyroid cancer is usually asymptomatic in early stages and often discovered incidentally. As the tumor enlarges or invades adjacent structures, the following may develop:

  1. Painless neck lump
    Most common first sign—unilateral, firm, poorly mobile on swallowing, slowly but steadily enlarging .
  2. Hoarseness
    Persistent and unrelenting hoarseness due to recurrent laryngeal nerve invasion and vocal-cord palsy .
  3. Dysphagia
    Compression or invasion of the oesophageal entrance causes globus sensation and progressive difficulty swallowing solids .
  4. Dyspnoea
    Tracheal compression or intraluminal growth produces inspiratory stridor and orthopnoea that worsen when lying flat .
  5. Cervical lymph-node swelling
    Firm, matted nodes in the lateral neck often indicate regional metastasis .
  6. Throat or referred ear pain
    Late-stage perineural invasion leads to persistent sore throat or ipsilateral otalgia .
  7. Less common features
    Medullary carcinoma may secrete bioactive substances causing diarrhoea and flushing; anaplastic cancer presents with rapidly enlarging mass and severe airway compromise .

Any neck lump that is hard, progressively enlarging and fixed, or symptoms of hoarseness or dysphagia lasting >2 weeks, warrants urgent ultrasound and fine-needle aspiration.

SymptomTypical FeaturesImplication
Neck lumpPainless, firm, moves poorly on swallowingPrimary tumor
HoarsenessPersistent, no improvement with restRecurrent laryngeal nerve invasion
DysphagiaGradual, starts with solidsOesophageal compression
DyspnoeaInspiratory stridor, worsens supineTracheal involvement
Lateral neck nodesHard, matted, fixedRegional metastasis
PainThroat or referred otalgiaAdvanced disease
Systemic (medullary)Diarrhoea, flushingHormone secretion