Most gallbladder polyps are found by chance and produce no symptoms at all, especially when smaller than 6 mm. When complaints do occur they are usually caused by the polyp obstructing the cystic duct, by associated gallstones, or by detachment of cholesterol fragments that behave like microliths.
- Episodic right-upper-quadrant pain
A dull or colicky ache begins 30–60 min after a fatty meal, may last several hours and can radiate to the right scapula—mimicking classic biliary colic. - Nausea and occasional vomiting
Gastric stasis and bile-duct spasm produce queasiness; vomiting may relieve the discomfort. - Dyspepsia and bloating
Patients report early satiety, eructation, or vague upper-abdominal heaviness unrelated to meals. - Jaundice (rare)
A large polyp that prolapses into the common bile duct can cause conjugated hyper-bilirubinaemia with dark urine and pale stools. - Acute cholecystitis picture
Continuous pain, local tenderness, low-grade fever and leukocytosis develop if the polyp blocks the cystic neck and precipitates inflammation. - Pancreatitis or hemobilia (very rare)
Transient obstruction of the pancreatic duct or bleeding from a friable polyp can produce epigastric pain radiating to the back or melena.
Because symptoms overlap with gallstone disease, any new biliary-type pain in a patient known to carry polyps should prompt repeat imaging to look for growth or co-existing stones.
| Symptom | Typical Presentation |
|---|---|
| RUQ colic | Post-prandial, radiates to scapula |
| Nausea/bloating | Early satiety, eructation |
| Jaundice | Large polyp blocks bile duct |
| Acute cholecystitis | Constant pain, fever, Murphy sign |
| Pancreatitis | Epigastric pain ↑ amylase |
| Hemobilia | Upper GI bleeding, melena |