Main Clinical Manifestations of Breast Tumours

Breast tumours comprise a spectrum ranging from benign fibro-epithelial lesions to invasive malignancies. Symptom expression reflects histological subtype, anatomical location, and biological behaviour. Early recognition allows accurate triage between conservative follow-up and definitive oncological therapy.

  1. Painless palpable mass
    Most tumours present as a discrete, firm nodule with variable mobility. Benign lesions (fibroadenoma) are smooth and slippery; malignant masses display irregular, spiculated borders and may fix to pectoral fascia or skin.
  2. Nipple-areolar changes
    Recent inversion, persistent eczema-like scaling, or spontaneous serosanguinous/bloody discharge suggests underlying malignancy. Ulceration and malodour indicate locally advanced disease.
  3. Skin alterations
    Dimpling along Cooper ligaments, peau d’orange from lymphatic obstruction, and diffuse erythematous induration (inflammatory carcinoma) are pathognomonic for malignancy. Benign tumours do not alter overlying skin.
  4. Axillary and supraclavicular lymphadenopathy
    Firm, matted, non-tender nodes ≥1 cm imply regional metastatic spread; fixation to deep structures signals extra-nodal extension.
  5. Cyclical vs. progressive pain
    Benign proliferations often produce cyclical mastalgia; persistent, progressive pain without relation to menses raises concern for malignancy or phyllodes tumour.
  6. Multifocality and bilateral disease
    Multiple synchronous masses may represent fibroadenomatosis or multifocal carcinoma; contralateral involvement suggests genetic predisposition (e.g., BRCA1/2).
  7. Rapid growth or sudden change
    Size increase >20 % within 6 weeks, new skin tethering, or appearance of satellite nodules mandates core biopsy to exclude high-grade malignancy or sarcomatoid transformation.
  8. Systemic and metastatic features
    Unintentional weight loss, persistent fatigue, bone pain, pleuritic cough, or neurological deficits indicate advanced malignant disease with distant organ involvement.
Symptom / SignTypical Presentation
Palpable massSmooth (benign) vs. irregular, fixed (malignant)
Nipple changesInversion, eczema, bloody discharge
Skin signsDimpling, peau d’orange, erythema (malignant)
Lymph nodesFirm, matted, ≥1 cm (metastatic)
PainCyclical (benign) vs. persistent (malignant)
MultifocalityMultiple synchronous or bilateral masses
Rapid change>20 %/6 weeks, tethering, satellites
SystemicWeight loss, bone pain, neurologic deficits