What is the relationship between tumor differentiation and malignancy?
Tumor differentiation is intrinsically linked to its malignancy. Generally, the lower the degree of differentiation in a tumor, the higher its malignancy tends to be, and vice versa. The differentiation of a tumor refers to how closely tumor cells resemble normal cells. Well-differentiated tumors have cells that are morphologically and structurally similar to normal cells, grow slowly, and are relatively less aggressive. These tumors usually respond well to treatment and have a better prognosis for patients. In contrast, poorly differentiated tumors have cells that are markedly different from normal cells, with abnormal shapes and disorganized structures. They grow rapidly and... Learn more