Main Clinical Manifestations of Mammary Hyperplasia

Mammary hyperplasia (fibrocystic change or benign proliferative breast disease) encompasses a spectrum of hormonally responsive stromal and epithelial alterations. Symptoms fluctuate with the menstrual cycle and often regress spontaneously; however, pronounced changes require exclusion of malignancy.

  1. Cyclic mastalgia
    Bilateral, dull or heavy pain most prominent in the upper outer quadrants, beginning 3–7 days before menses and resolving with menstruation. Pain may radiate to the axilla or medial arm.
  2. Nodular or glandular thickening
    Multiple, small, mobile “lumps” with ill-defined borders create a cobble-stone or granular consistency that merges with surrounding tissue.
  3. Premenstrual breast swelling and heaviness
    Diffuse enlargement of one or both breasts, accompanied by tightness of brassiere and mild nipple hypersensitivity.
  4. Cystic fluctuation
    Large cysts produce discrete, well-circumscribed, resilient masses that may transilluminate; aspiration yields straw-coloured or greenish fluid.
  5. Nipple discharge
    Multiduct, serous or green-brown discharge is common; frank blood or persistent single-duct discharge mandates cytological evaluation.
  6. Axillary discomfort
    Tender, mobile lymph nodes < 1 cm accompany cyclic inflammation; firm or fixed nodes require biopsy.
  7. Post-menopausal regression
    Symptoms diminish spontaneously after ovarian failure; new palpable masses in post-menopausal women are considered malignant until proven otherwise.
  8. Psychological impact
    Fear of cancer amplifies symptom perception; reassurance following negative imaging and clinical follow-up often reduces pain scores.
Symptom / SignTypical Presentation
Cyclic mastalgiaBilateral, dull, premenstrual
Nodular thickeningMultiple, small, ill-defined lumps
SwellingDiffuse, heavy, premenstrual
Cystic massDiscrete, fluctuant, transilluminates
DischargeMultiduct, serous/green; blood → investigate
Axillary nodesTender, mobile < 1 cm
Post-menopauseSymptoms regress; new mass → biopsy
PsychologicalAnxiety-driven amplification