Mammary hyperplasia (fibrocystic change or benign proliferative breast disease) encompasses a spectrum of hormonally responsive stromal and epithelial alterations. Symptoms fluctuate with the menstrual cycle and often regress spontaneously; however, pronounced changes require exclusion of malignancy. Cyclic mastalgiaBilateral, dull or heavy pain most prominent in the upper outer quadrants, beginning 3–7 days before menses and resolving with menstruation. Pain may radiate to the axilla or medial arm. Nodular or glandular thickeningMultiple, small, mobile “lumps” with ill-defined borders create a cobble-stone or granular consistency that merges with surrounding tissue. Premenstrual breast swelling and heavinessDiffuse enlargement of one or both breasts, accompanied... Learn more