Primary liver cancer (hepatocellular carcinoma, HCC) often begins silently; early-stage tumors rarely cause pain or obvious changes. As the lesion enlarges or invades adjacent structures, the following complaints typically appear: Right-upper-quadrant discomfortA dull, continuous ache or heaviness develops beneath the ribs and may radiate to the back or right shoulder. Palpable mass or abdominal swellingPatients or clinicians can feel a firm, nodular liver edge below the costal margin; progressive enlargement can produce visible asymmetry of the abdomen. Unintended weight loss & anorexiaRapid loss of >5 % body weight within weeks, early satiety and loss of interest in food are common... Learn more