Empty Sella Syndrome: An Overview Empty sella syndrome is not a tumor but an imaging finding characterized by the descent of the subarachnoid space into the pituitary fossa through an enlarged diaphragma sellae, causing an enlargement of the sella turcica and compression of the pituitary gland. This article delves into various aspects of empty sella syndrome to provide a comprehensive understanding. Causes Empty sella syndrome may be associated with congenital larger diaphragma sellae, increased cerebrospinal fluid pressure, and hormonal factors. These factors lead to the compression of pituitary tissue, allowing the subarachnoid space to herniate into the sella. Symptoms Most... Learn more