Chronic lymphadenitis is a prolonged, low-grade inflammation of lymph nodes, usually lasting more than six weeks. It often follows inadequately treated acute infections, mycobacterial disease, or persistent immune stimulation. Typical features include:
- Painless or mildly tender rubbery nodes
Lymph nodes enlarge slowly to 1–3 cm, feel firm but not hard, and remain mobile beneath the skin. - Persistent swelling without redness
Overlying skin looks normal; heat, erythema, and fluctuation are absent unless secondary infection occurs. - Waxing and waning course
Nodes may reduce slightly between flares but never return to baseline size, especially after minor upper-respiratory infections. - Mild systemic symptoms
Low-grade evening fever, easy fatigability, or night sweats can appear, but high fever and rigors are uncommon. - Sinus tract or matting (special settings)
In mycobacterial disease the overlying skin becomes thin, violaceous, and may form a chronic draining sinus; several nodes can mat together. - Regional source signs
Look for chronic dental caries, tonsillar infection, tuberculosis contact, or cat-scratch history that sustains the nodal reaction. - Absence of weight loss and B-symptoms
Unlike lymphoma, chronic lymphadenitis rarely produces >10 % weight loss, drenching sweats, or hepatosplenomegaly; if present, biopsy is mandatory.
Any node >2 cm that remains palpable for more than six weeks, becomes progressively firmer, or develops overlying skin changes warrants ultrasound, chest X-ray, and fine-needle or excisional biopsy to exclude tuberculosis or neoplasia.
| Feature | Chronic Lymphadenitis | Red-flag for Other Pathology |
|---|---|---|
| Size | 1–3 cm, rubbery | >3 cm, rock-hard or fixed |
| Pain | Absent or mild | Increasing or severe |
| Skin | Normal colour | Violaceous, ulcerated, sinus |
| Fever | Low-grade or none | >38.5 °C, drenching sweats |
| Course | Wax and wane, stable | Progressive enlargement |
| Systemic | No weight loss | Weight loss, hepatosplenomegaly |