Intrahepatic cholangiocarcinoma (ICC) arises from bile ducts within the liver parenchyma. Early lesions are usually asymptomatic; as the tumor enlarges or metastasizes, the following complaints typically appear: Right-upper-quadrant painA dull, continuous ache or vague fullness beneath the ribs is the most frequent early symptom; it may radiate to the back or shoulder. Palpable mass or hepatomegalyPatients or clinicians can feel a firm, nodular liver edge or localized lump that moves with respiration. Unintended weight loss & anorexiaRapid loss of >5 % body weight within weeks, early satiety and loss of interest in food are common systemic effects. Fatigue and night... Learn more