Gallbladder stones (cholelithiasis) can remain silent for years, but when they obstruct the cystic duct or migrate into the bile duct they produce a characteristic symptom cluster: Biliary colicSudden, steady pain in the right upper quadrant or epigastrium builds over 15–30 minutes, lasts 30 min – several hours, and may radiate to the right shoulder or back; it is not relieved by positional change, bowel movement, or antacids . Post-prandial triggerPain typically follows a fatty or large meal as gall-bladder contraction forces a stone against the duct opening . Nausea and vomitingGastric stasis and vagal stimulation produce pronounced nausea with... Learn more