Acute appendicitis results from luminal obstruction followed by bacterial overgrowth and rapid inflammation. Cardinal features in chronological order are: Migratory painVague periumbilical or upper-abdominal discomfort migrates to the right lower quadrant within 4–6 h and intensifies with movement, coughing or palpation. Gastro-intestinal upsetAnorexia, nausea and often vomiting; loose stools or constipation may mislead toward gastroenteritis. FeverLow-grade 37–38 °C early, rising >38.5 °C as inflammation advances; elderly or immunocompromised patients may remain afebrile. Peritoneal signsMaximal tenderness at McBurney point, rebound pain, guarding and hypo-active bowel sounds indicate parietal peritoneal irritation. Systemic toxicityTachycardia, malaise, thirst; high fever with pallor or hypotension suggests... Learn more