Vasculitis means blood vessels are inflamed. Because vessels feed every organ, symptoms can pop up anywhere, but most people notice pain, color changes, and fatigue first. Localized pain is the early clue. It feels like a deep bruise along an artery or vein, often with a burning or throbbing quality. Color changes show up next. The skin turns red, purple, or blotchy, especially over the arms, legs, or face. Low-grade fever and night sweats are common. You feel cold one minute, hot the next, and wake up soaked. Fatigue is constant. Legs feel heavy, and you need naps even after... Learn more