Tetanus Shot Administration and Aftercare Administering a tetanus shot, or tetanus toxoid, is a critical procedure when there’s a risk of infection from a wound. The process begins with a skin test to determine if an individual is allergic to the vaccine. If the skin test results are negative, the injection can be safely administered into the deltoid muscle or the gluteal muscle. In cases where the skin test is positive, a desensitization injection method can be used, or alternatively, tetanus immune globulin can be injected into the gluteal muscle. Following the administration of a tetanus shot, it’s essential to... Learn more