Understanding CA125 in Ovarian Cancer CA-125, also known as cancer antigen 125, is a high-molecular-weight glycoprotein. It is not present in normal ovarian tissue but is found in elevated levels in the serum of patients with ovarian epithelial tumors, making it a valuable tool for early detection and monitoring of ovarian cancer. Additionally, serum CA-125 levels may be elevated in patients with non-ovarian malignancies such as fallopian tube adenocarcinoma, endometrial cancer, cervical cancer, pancreatic cancer, colorectal cancer, breast cancer, and lung cancer, although with a lower positive predictive accuracy compared to ovarian cancer. For individuals with ovarian cancer, the monitoring... Learn more