Sudden Ankle Pain: Causes and Treatments Causes of Sudden Ankle Pain Without Injury Experiencing ankle pain without any apparent injury can be concerning and may signal underlying health issues. It’s crucial not to ignore this symptom as it could be indicative of various conditions. Below is a detailed analysis and approach to dealing with this phenomenon. Gouty Arthritis One common cause of sudden ankle pain is gouty arthritis, which occurs when uric acid crystals accumulate in the joints, triggering an inflammatory response and causing severe pain. Managing gouty arthritis often involves the use of urate-lowering medications such as allopurinol and... Learn more